glycyrrhetinic acid การใช้

• The structure of glycyrrhetinic acid is similar to that of cortisone.
• :: : The article names given by Zymatik are glycyrrhizin and glycyrrhetinic acid.
• After oral ingestion, glycyrrhizin is first hydrolysed to 18?-glycyrrhetinic acid by intestinal bacteria.
• Both glycyrrhetinic acid and carbenoxolone have a modulatory effect on neural signaling through gap junction channels.
• After complete absorption from the gut, ?-glycyrrhetinic acid is metabolised to 3?-monoglucuronyl-18?-glycyrrhetinic acid in the liver.
• After complete absorption from the gut, ?-glycyrrhetinic acid is metabolised to 3?-monoglucuronyl-18?-glycyrrhetinic acid in the liver.
• 3-?-D-( Monoglucuronyl )-18-?-glycyrrhetinic acid, a metabolite of glycyrrhetinic acid, inhibits the conversion of'active'cortisol to'inactive'cortisone in the kidneys.
• 3-?-D-( Monoglucuronyl )-18-?-glycyrrhetinic acid, a metabolite of glycyrrhetinic acid, inhibits the conversion of'active'cortisol to'inactive'cortisone in the kidneys.
• "' Carbenoxolone "'( "'CBX "') is a glycyrrhetinic acid derivative with a steroid-like structure, similar to substances found in the root of the licorice plant.
• This enzyme co-localizes with intracellular adrenal steroid receptors and converts cortisol into cortisone, a relatively inactive metabolite with little affinity for the MR . Liquorice, which contains glycyrrhetinic acid, can inhibit 11 ?-HSD and lead to a mineralocorticoid excess syndrome.